Since we found a severe morphological change in the GPC3 transduced MDA-MB231 cells - from fibroblast-like to squamous-epithelial cell shape - besides modulation on the actin cytoskeleton, growth, death, migration, and in vivo behavior, in MCF-7-sh GPC3 and MDA-MB231-GPC3 cells, we decided to study the potential role of GPC3 in the EMT of breast cancer cells. The gene discussed is GPC3; the disease is breast carcinoma.