Furthermore, K-rasG12D-induced leukemia was significantly delayed in recipient mice transplanted with Fanca−/− Luc-LSL-K-rasG12D/CreER LSK cells expressing PRMT5 compared with the recipient mice of donor Fanca−/− Luc-LSL-K-rasG12D/CreER LSK cells carrying the vector control virus (Figure 4E). The gene discussed is PRMT5; the disease is leukemia.