ANRIL was transcribed in the opposite direction from INK4b-ARF-INK4a gene cluster encoding three tumor suppressors: p15(INK4b), p14(ARF), and p16(INK4a), and it has been suggested that ANRIL repressed the expression of p15(INK4b), p14(ARF), and p16(INK4a) [19]. The gene discussed is CDKN2B; the disease is neoplasm.