Mechanically, the story behind YAP/TAZ is rather complex as the Hippo pathway cross talks with multiple signaling pathways [26–28] involved in CRC, and some of these pathways, such as the Wnt pathway [26, 28–32], is aberrantly activated and mutations in components of the Wnt pathway, most often in APC, are found in 90% of colon cancers. The gene discussed is YAP1; the disease is colorectal carcinoma.