The result from CRC cells transfected with DnGs showed the levels of pLATS1 and pYAP were decreased, even though further treatment of ω-3 PUFAs could not reverse this decreasing tendency, suggesting that Gαs protein is essential for ω-3 PUFAs-induced YAP phosphorylation (Figure 6G and 6H). Here, YAP1 is linked to colorectal carcinoma.