TNFRSF10B and neoplasm: Firstly, since acidic pH in the Golgi lumen is essential for correct protein glycosylation during their transit through the organelle and DR5 O-linked glycosylation controls tumor cell sensitivity to TRAIL [19, 20], benzyl-α-galNAc and PUGNAc were used to inhibit or enhance this post-translational modification, respectively.