TOP1 and cancer: When using this best cutoff (0.0002125) to the test gene fusion set of 35 cancers, we identified 269(over 50%) out of the 483 previously known high-risk cancer gene fusions Figure 1D, Supplementary Table S1, including 189 out of 287 for haematological Figure 1D and 1E, Supplementary Table S1 such as HMGA2-COX6C, HMGA2-CCNB1IP1 of uterine cancer and 80 out of 196 for solid Figure 1D and 1F, Supplementaray Table S1 such as NUP98-TOP1, NSD1-NUP98 of MDS.