Taken together, we found 13 previously known high-risk gene fusions of breast cancer such as BCAS3-BCAS4, NOTCH- NUP214, MED13- BCAS3 and CARM-SMARCA4, and 8 potential drivers such as SULF2-ZNF217, MED1-ACSF2 (Table 3, Table 4). The gene discussed is SULF2; the disease is breast cancer.