NOTCH1 and breast carcinoma: Moreover, Kaplan-Meier survival analysis [39] revealed that high NUMB expression was associated with decreased distant disease-free survival (DDFS p = 0.0138) of breast cancer patients (Figure 8C, left), while high Notch1 expression was associated with increased DDFS (p = 0.0035) of breast cancer patients (Figure 8C, middle).