In PBC patients who reached an end-point in the follow-up period (liver transplantation or death), the activity of ATX was significantly higher than in the remaining patients (13.3 ± 3.4 vs. 9.6 ± 4.4 nmol mL−1 min−1, P < 0.001; Fig. 4A). The gene discussed is ENPP2; the disease is primary biliary cholangitis.