An analysis of all patients revealed that the mean ATX activity of patients in the PBC group was significantly higher than in patients in the PSC group (10.2 ± 4.4 vs. 7.3 ± 3.4 nmol mL−1 min−1, P < 0.0001; Fig. 1). The gene discussed is ENPP2; the disease is primary biliary cholangitis.