FGF2 and bone neoplasm: It plays a crucial positive role in bone remodeling,1,2 while the in vitro cell-based analysis suggested a severe negative role in bone diseases.54 In this study, we generated a neutralizing anti-FGF2 aptamer, APT-F2P, and demonstrated that sequestering FGF2 activity by APT-F2P significantly reduced severity of joint disease and bone destruction in CIA, GPI mice, and OVX rats, and further ameliorated bone cancer pain in FBC mice.