However, acute myeloid leukemia can result from loss‐of‐function mutations in SPI1 or reduced Spi1 expression (Sive et al., 2016; Will et al., 2015), while induced expression of SPI1 in myeloid leukemia cells restores their differentiation and reduces their proliferation rates (Tkatchenko et al., 2001). The gene discussed is SPI1; the disease is myeloid leukemia.