Similarly, over-expression of interleukin 1 alpha (Il1a) in skin using a keratin 14-Il1a transgene conferred complete resistance to the two-stage DMBA/TPA protocol for tumor development by a mechanism that was proposed to involve increased neutrophil infiltration [79], the phenotype also induced in the present studies by Pannexin inhibition. Here, KRT14 is linked to neoplasm.