The results demonstrated that the expression level of CCBE1 in GIST tissues was closely correlated with NIH risk degree (p < 0.001), tumor size (p < 0.001), tumor site (p = 0.012), mitotic figures (p = 0.008), Ki67 classification (p = 0.005), recurrence (p = 0.001) and invasion (p < 0.001). The gene discussed is MKI67; the disease is gastrointestinal stromal tumor.