Although insulin resistance was anticipated in these PPARγ-deficient, severely lipodystrophic animals, circulating insulin levels were “inappropriately” normal (7.6 +/- 10.1 ng/ml in MORE+/Cre:PPARγ-/F, n = 7, vs. 7.4 +/- 7.4 ng/ml in MORE+/Cre:PPARγ+/F, n = 6. This evidence concerns the gene INS and Insulin resistance.