MMP9 and epilepsy: Later, we blocked epileptogenesis with NMDA receptor antagonist, and we showed that once there was no development of epilepsy, there was no Mmp-9 proximal promoter demethylation, and accordingly there was no upregulation of Mmp-9 expression, which suggested a strict dependence of the Mmp-9 mRNA elevation on the demethylation of its gene promoter.