BRD2 and granulosa cell tumor: It has been reported that the cyclin D2 (CCND2) expression is localized to the granulosa cells of the ovarian follicles [53], FSH acutely increased granulosa cell CCND2 mRNA abundance and CCND2 protein content as well as proliferation [54], and human granulosa cell tumors display high levels of CCND2 mRNA compared with wild-type ovaries [53].