Accumulating evidence suggests that over-expression of CCR7 is correlated with lymphatic invasion; CCL21/CCR7 regulated migration and metastasis in a variety of lung, esophageal, and pancreatic cancer cells, possibly allowing them to access the lymphatic system and spread to regional lymph nodes[14–16, 26–28]. This evidence concerns the gene CCL21 and familial pancreatic carcinoma.