Transcription factors, such as Snail, Slug and Twist have been shown to act as vital controller of the EMT [11].An emerging concept for metastasis suggests that cellular plasticity associated with EMT is critical for the ability of cancer cells to disseminate from the primary tumor site and survive circulation, and for their enhanced migratory capacity, invasiveness, and increased resistance to apoptosis. Here, TWIST1 is linked to cancer.