However, the correlations between FA and RD values of the genu of the corpus callosum and SLC6A4 DNA methylation at CpG4 in healthy controls were not significantly higher compared with patients with MDD (FA: z=0.57, P>0.1; RD: z=−1.04, P>0.1). The gene discussed is SLC6A4; the disease is major depressive disorder.