Impaired insulin sensitivity was prevalent in both PCOS subgroups in terms of decreased ISI-Comp, which was significantly related to dyslipidemia (triglycerides: rho = -0.35, p = 0.011; LDL-cholesterol: rho = -0.35, p = 0.010; HDL-cholesterol: rho = 0.55, p<0.001) and obesity (BMI: rho = -0.59, p<0.001, WC: rho = -0.50, p<0.001). This evidence concerns the gene INS and metabolic syndrome.