Likewise, Dunaif et al. found that peripheral insulin sensitivity is decreased about 30–40% in lean and obese females with PCOS (diagnosed by anovulation in addition to hyperandrogenism) using the hyperinsulinemic euglycemic clamp technique [32, 33], what is comparable to the magnitude of insulin resistance observed in subjects with overt type 2 diabetes [6]. This evidence concerns the gene INS and type 2 diabetes mellitus.