INS and polycystic ovary syndrome: Dunaif et al. (1996) reported impaired ß-cell function in lean and obese women with PCOS by using the FSIGT (frequently sampled intravenous glucose tolerance test) method, whereby the disposition index was calculated as the product of (minimal model derived) insulin sensitivity and acute insulin response to glucose (AIRg, a parameter reflecting first phase insulin secretion) [37].