MAPT and Cognitive impairment: These include that the head must be struck directly; that the impacts should occur with high velocity and rapid acceleration of the head, both rotational and angular [11–13]; that the injuries should be mild enough not to cause more severe injury such as edema, neuronal damage or hemorrhage [11, 14]; and that long-term manifestations of the injury should reflect the onset of CTE, including mild cognitive deficits, changes in mood and the appearance of neuropathological features such as tau phosphorylation [15–17].