ERBB2 and breast cancer: Reimbursement for adjuvant trastuzumab in node-positive HER2+ early breast cancer is not generally controversial in high-income countries, and there is evidence to suggest that there is a higher willingness to pay for cancer treatments; for instance, the UK government established the Cancer Drugs Fund in 2010 to pay for cancer treatments that have, among other things, been rejected by NICE under its reference case analysis.