Prkcb encodes protein kinase C β (PRKCB), and it has been proved that inhibition of PRKCB isoform ameliorates methylglyoxal advanced glycation end product-induced cardiomyocyte contractile dysfunction, possibly through modulation of oxidative stress, O2(-) generation, cell death, apoptosis and mitochondrial injury[46].We speculated that Prkcb could play a protective role in the HF progress. The gene discussed is PRKCB; the disease is hydrops fetalis.