Among these 51 studies, 24 studies reported the association of STAT3 expression with clinicopathological parameters or poorer overall survival of colorectal cancer, 21 studies did not supply sufficient data, 3 studies were published delicately, 2 studies did not use immunohistochemical methods to detect the expression of p-STAT3 and 1 study was not from the Chinese core journals. The gene discussed is STAT3; the disease is colorectal cancer.