LMNA and lipodystrophy: Interestingly, most mutations in patients with FPLD occur in the carboxy terminal domain of lamin A/C, while cardiomyopathy has been associated with mutations in amino terminal domain of the lamin A/C in FPLD patients.2 Several heterozygous mutations in LMNA like the R28W, R60G, R62G, and D192V have been reported to be associated with lipodystrophy and cardiomyopathy.