Moreover, Liu et al. [21] have found that quercetin prevents Pb-induced ERS at least in part due to its modulation of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) and inositol-requiring enzyme 1 (IRE1)/JNK signaling pathways. The gene discussed is AKT1; the disease is amelogenesis imperfecta type 1G.