Overall, the main findings of the present study are that (1) IL-1β, IL-6, and TNF-α and their receptors in membrane expression are upregulated in the dl-PAG of PD rats; and (2) blocking those individual receptors in this brain region attenuates hypersensitive responses to mechanical and thermal stimuli in PD rats likely by improving impaired GABAergic descending inhibitory system. This evidence concerns the gene IL1B and Parkinson disease.