These included pathways involved in neurotransmission (glutamatergic synapse, DA synapse, retrogade endocannabinoid signaling, GABAergic synapse, and cholinergic synapse), neurodevelopment (Rap1 signaling, neuroactive ligand–receptor interaction), and other functions, such as circadian entrainment, insulin secretion, hypertropic cardiomyopathy, dilated cardiomyopathy, the estrogen signaling pathway, and endocytosis. The gene discussed is INS; the disease is dilated cardiomyopathy.