We found the brain phenotype components were related to differences in expression of a neuroactive ligand–receptor interaction pathway, which has been linked to neurodevelopment and is associated with various psychiatric disorders (52, 53), and also to a specific signal transduction pathway, i.e., Rap1 (ras-related protein 1), whose pathway involves cell adhesion and regulation of mitogen-activated protein kinase that are important for neural development (54, 55) in the form of neocortical neuronal migration and lamination (56). This evidence concerns the gene WNK2 and psychiatric disorder.