An analysis of the substrates using Enrichment by Biological Process indicated that Fbxo7 ubiquitinates multiple proteins that have an impact on ErbB2 (10 substrates), Wnt (10 substrates), and MAPK (13 substrates) signalling, ribosomes (9 substrates), axonal guidance (10 substrates), and pathways in cancer (16 substrates). The gene discussed is ERBB2; the disease is cancer.