IL23R and inflammatory bowel disease: In the context of the few other established protective variants in IBD, including the coding IL23R variants (p.V362I, MAF=1.27%, OR=0.72 (0.63–0.83); p.G149R, MAF=0.45%, OR=0.60 (0.45–.0.79)) and the splice disrupting CARD9 variant (c.IVS11+1G>C, MAF=0.58%, OR=0.29 (0.22–0.37))7, R179X exerts a comparable protective effect.