When stratified by TERT and MGMT statuses, their association with OS and PFS were as follows: 1) In the patients with MGMT methylated tumors, TERT status was not associated with either OS or PFS (P > 0.05, Log-rank test) 2) In the patients with MGMT unmethylated tumors, those with TERT mutant tumors showed shorter OS and PFS than those with TERT wild-type tumors (P < 0.05, Log-rank test); 3) lack of MGMT promoter methylation was associated with shorter OS and PFS in both TERT wild-type (Group C GBM) and TERT mutant (Group D GBM) groups (P < 0.05, Log-rank test; Fig. 4). The gene discussed is TERT; the disease is glioblastoma.