On the other hand, the association of DRB1*15:02, which differed from the second daughter’s HLA haplotype, with autoimmune liver disease, including the overlapping features of PBC and AIH within the same family, remains unknown, although DR15 has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) [4, 15]. Here, HLA-DRB1 is linked to primary biliary cholangitis.