LRRK2 and Parkinson disease: To determine if PD patient PBMCs continued to respond similarly to control PBMCs with lower doses of LRRK2 inhibitors, we repeated the experiments in a second cohort of subjects, this time using GSK2578215A at 0.125 and 0.063 μM and LRRK2-IN1 at 0.25 and 0.125 μM.