The mRNA expression levels of miRNA biogenesis proteins (Dicer, drosha, Ago-1,Ago-2 and Exportin 5) were found significantly reduced (except for drosha inSLE) in neutrophils from APS and SLE patients (Fig. 3A).No changes were found in monocytes (data not shown). The gene discussed is AGO2; the disease is systemic lupus erythematosus.