Monocyte transfections with miR-124a and miR-125a mimics, either separately orsimultaneously, caused a reduction in the expression of target molecules relatedto the atherothrombotic process in APS and SLE, such as MCP-1, IL-6, IL6R, IL-8,ERK, STAT-3, p38 MAPK and peroxides (Fig. 7A–F).The simultaneous transfection with both pre-miRNAs did not potentiate theinhibitory effect caused by each miRNA mimic administered separately, butincreased the global number of molecules targeted. The gene discussed is IL6; the disease is autoimmune polyendocrinopathy.