CD8A and malaria: In order to determine the role of human CD8+ T cells in mediating the protective anti-malaria immune response observed in HIS-CD8 mice, a group of AdPfCSP-immunized HIS-CD8 mice received two IP injections of the monoclonal anti-human CD8+ T-cell antibody, MT807R1 (0.1 mg/mouse/injection) [32], 5 days and 8 days after AdPfCSP immunization (Fig.3A).