uPAR is strongly involved in wound healing, clot lysis, tissue remodeling through binding to and activating pro-uPA, which in turn stimulates further invasion-promoting factors such as plasminogen and pro-matrixmetalloproteases (pro-MMPs) followed by the degradation of the extracellular matrix (ECM) leading to migration and invasion of tumour cells [14]. This evidence concerns the gene PLG and neoplasm.