Furthermore, uPA expression alone significantly correlated with PAI-1, cathepsin D, plasminogen and Ki67 but not with the expression of uPAR, cathepsin B or other clinical parameters, whereas uPA-uPAR complexes significantly correlated with the expression of both cathepsins (B and D), IGF1R and inversely with the tumour size. The gene discussed is CTSB; the disease is neoplasm.