Cox proportional hazard regression analysis showed rs4027405 and rs1890908 were significantly associated with OS after adjustment for age, body mass index (BMI), smoking status, drinking status, TACE status, serum AFP, radical resection, pathological grade, cirrhosis, intrahepatic metastasis, vascular invasion, antiviral therapies, child-pugh class, BCLC stage and PVTT (Table 5 and Fig. 5). Here, AFP is linked to Cirrhosis.