AFP and hepatocellular carcinoma: Moreover, univariate and multivariate Cox regression analyses indicated that rs4027405 and rs1890908 were independent predictors of poor OS of HBV-related HCC patients, and it combined with serum AFP can suggest that patients with AFP > 400 ng/ml and higher p21 expression allele have significantly higher risk for death than those with AFP ≤ 400 ng/ml and lower p21 expression allele.