AFP and liver cancer: There were no significant differences in the age, gender, BMI, race, smoking status, drinking status, Barcelona Clinic Liver Cancer (BCLC) stage, serum alpha fetoprotein (AFP) level, transcatheter arterial chemoembolization (TACE) status, pathological grade and TP53 249Ser mutation between p21 negative group and p21 positive group (P > 0.05).