Univariate analysis showed that age > 70 years, BMI < 20 kg/m2, ECOG PS ≥ 2, ACCI ≥ 4, high lactate dehydrogenase, low absolute lymphocyte count (≤ 1.1 × 109/L), platelets < 100 × 109/L, serum creatinine ≥ 2 mg/dL, serum albumin < 3.5 g/dL, and serum β2-microglobulin > 5500 mg/L were significantly associated with EM. The gene discussed is HLA-G; the disease is erythema multiforme.