On the other hand, the lncRNA MRAK043570 is significantly associated with the PI3K-Akt, mTOR, FoxO and AMPK signalling pathways, which are altered in brains with AD [35, 36]; in addition, all these pathways are linked to the regulation of autophagy, which is strongly regarded as one of the major pathogenic mechanisms of AD [37, 38]. This evidence concerns the gene AKT1 and Alzheimer disease.