Case–case analysis of tumours with and without EGFR mutations showed statistically significant allelic differentiation for four of the seven SNPs, rs2736100, rs3817963, rs2179920 and rs2495239, after Bonferroni correction (Supplementary Fig. 3 and Supplementary Table 7), indicating that these SNPs are significantly more strongly associated with the risk of LADC with than without EGFR mutation (that is, PTrend<7.1 × 10−3 calculated as 0.05/7). The gene discussed is EGFR; the disease is neoplasm.