TERT and laryngeal neoplasm: Remarkably, 228C > T and 250C > T mutations in the TERT promoter are more frequent in laryngeal tumors in smokers compared to that in non-smokers and are independently associated with poor overall survival (OS) [46].TERT promoter activity can be modified by a common polymorphism within the preexisting ETS2 binding site in the TERT promoter with patients with the rs2736098 variant and in particular those exposed to tobacco and alcohol having a lower risk of SCC of the oropharynx [160].