MAPT and tauopathy: Similarly, axonal transport defects and cognitive deficits of PS19Tg mice (expressing the P301S mutant form of human tau) and various other mouse and fly tauopathy models were shown to be rescued by microtubule-stabilising drugs (Gozes, 2011; Quraishe et al., 2013; Shemesh and Spira, 2011; Zhang et al., 2012), suggesting that the mechanisms we described may be conserved and relevant to disease.