This hypothesis is attractive because the well-conserved mammalian spectraplakin Dystonin is already linked to a neurodegenerative disease (type VI hereditary sensory autonomic neuropathy; OMIM #614653;) (Ferrier et al., 2013), and its paralogue ACF7/MACF1 plays important roles during brain development (Goryunov et al., 2010; Ka and Kim, 2015). The gene discussed is MACF1; the disease is neurodegenerative disease.