These genes: SIX3, H19, PTPRD, WWOX, MAML2, PGR, TRPC6, MMP20, MMP13, MMP1, and MMP3 were involved in tumor progression of mucoepidermoid carcinoma, prostate adenocarcinoma, glioblastoma, pancreatic cancer, lung cancer, and epithelial breast cancer [50, 82–90]. The gene discussed is SIX3; the disease is neoplasm.