MMP1 and neoplasm: Basically, both chromosome 7 and 11 contain genes that are involved in the tumor progression such as EGFR, HGF, HOX, BRAF, PAFAH1B2, FLI1, and ETS1 [30–35], in particular LAMB1, MET, MMP1, CCND1, ORAOV1, FADD, PPFIA1, and CTTN genes which related to HNSCC [36–38].