SIRT2 and Sepsis: Fig 7B shows that while the vehicle treated DIO sepsis mice remained endotoxin tolerant during the hypo-inflammatory phase, the AK-7 treated mice showed endotoxin responsiveness similar to ob/ob mice. Thus, our data suggest that the hypo-inflammatory phase of sepsis is associated with increased SIRT2 expression in DIO mice as well. Moreover, SIRT-2 inhibition during the hypo-inflammatory phase in DIO mice with sepsis reverses the endotoxin tolerance similar to ob/ob mice.