Namely, GSTM1-null/GSTP1-variant/GSTA1 low-activity combination of genotypes, which was present in 94% of smokers with cRCC, as opposed to 70% in controls, increased the risk of cRCC up to 7.57 (95%CI:1.26–45.30,p = 0.02). This evidence concerns the gene GSTM1 and chromophobe renal cell carcinoma.