Since GSTs are involved in the biotransformation of several compounds recognized as risk factors for RCC [13], it is not surprising that cytosolic GST classes M1, T1 and P1 gained most attention in RCC as potential risk (GSTM1, GSTT1 and GSTP1) and chemoresistance determinants (GSTT1 and GSTP1) [6,7,11,12]. Here, HPGDS is linked to renal cell carcinoma.