In specific, we report that transfecting SK-LU-1 lung adenocarcinoma cells with miR-125b and/or wt-p53 plasmid loaded in HA-PEI/HA-PEG nanoparticles, we can overexpress these genes not only in the SK-LU-1 cells but also in the secreted exosomes. The gene discussed is TP53; the disease is lung adenocarcinoma.