Through non-viral transfection of KRAS/p53 mutant SK-LU-1 NSCLC cells with wt-p53 plasmid and hsa-miR-125b loaded in hyaluronic acid-poly(ethylene imine) and hyaluronic acid-poly(ethylene glycol) (HA-PEI/HA-PEG) blend nanoparticles, we try to indirectly modulate the payload in the exosomes secreted from these transfected SK-LU-1 cells. Here, TP53 is linked to non-small cell lung carcinoma.