TP53 and neoplasm: Role of miRNAs in regulating the balance between the M1 and M2 phenotypes of macrophages as well as impacting the recruitment of other immune cells in the tumor microenvironment is well established.16, 26, 29 Even recent studies from our group reported that that treatment with combination therapy of miR-125b and p53 encoding plasmid results in elevated M1 macrophages both in vitro and in vivo.