The Zhan lab91 described how kindlin-2 modulates the cisplatin-induced apoptosis and cell death of human glioma cells by regulating the AKT/JNK and AKT/p38 signaling pathways while the Zhang lab77 found kindlin-2 to activate the cisplatin-mediated cell death of prostate cancer cells through the regulation of the Bcl-xL cell death pathway. Here, AKT1 is linked to central nervous system cancer.