Another study identified CSNK1e (protein CK1ε) as a synthetic lethal target of MYC and N-MYC upregulated in neuroblastoma and other human cancers (Toyoshima et al., 2012), and upregulation of CK1ε would be expected to destabilize the clock through its promotion of PER degradation and activation of BMAL1 (Gallego and Virshup, 2007). This evidence concerns the gene CLOCK and cancer.