Among the AKR1 family, the aldose reductase subgroup-designated AKR family 1 member B (AKR1B) is one of the most characterized because of its involvement in human diseases, such as diabetic complications resulting from the ability of the former AKR family 1 member B1 (AKR1B1) to reduce glucose into sorbitol in a NADPH + H+-dependent manner during hyperglycemia. The gene discussed is AKR1B1; the disease is Hyperglycemia.