Lasso/Teneurin-2 is a bona fide cell-surface receptor (Tucker and Chiquet-Ehrismann, 2006; Silva et al., 2011; Beckmann et al., 2013; Boucard et al., 2014) and can be clearly detected on the cell surface when expressed in HEK293 (not shown) or mouse neuroblastoma NB2a cells (Figure 2). Here, CD177 is linked to neuroblastoma.