IL10 and Increased total eosinophil count: In OVA sensitized mice, the co-administration of VD3 plus OVA significantly inhibited the airway hyper-responsiveness and potentiated the AIT effect by further reducing serum OVA-specific IgE level, airway eosinophilia and Th2-related cytokines; the boosting effect of VD3 seems to be mediated by IL-10 and TGF-β, since the levels of these cytokines were elevated in the VD3-treated mice and the beneficial effect was abrogated in the presence of antibodies directed to these cytokines [14].