The Notch receptor Notch1 is the main driver of HSPC emergence from HE, likely downstream of its ligand Jagged1 (Gama-Norton et al., 2015, Hadland et al., 2015, Jang et al., 2015) and is thought to drive runx1 expression via Gata2 (Robert-Moreno et al., 2005). The gene discussed is RUNX1; the disease is hereditary elliptocytosis.